|
KMID : 0861420120160020106
|
|
Korean Journal of Nuclear Medicine Technology
2012 Volume.16 No. 2 p.106 ~ p.109
|
|
|
Production of 11C labeled Radiopharmaceuticals using [11C]CO2 Produced in the KOTRON-13
|
|
Lee Hong-Jin
Park Jun-Hyung
Moon Byung-Seok
Lee In-Won
Lee Byung-Chul
Kim Sang-Eun
|
|
|
Abstract
|
|
|
Purpose:The KOTRON-13 cyclotron was developed and installed in regional cyclotron centers to produce
short-lifetime medical radioisotopes. However, this cyclotron has limited capacity to produce 11C so far. In
present study, we developed an effective 11C target system combining with fluorine-18 target and applied to the
production of various 11C radiopharmaceuticals.
Materials and Methods: To develop the optimal 11C target
system and effective its cooling system, we designed the 11C target system by Stopping and Range of Ions in
Matter (SRIM) simulation program and considered the cavity pressure during irradiation at target grid. In this
investigation, we modified target materials, cavity shapes and the position of cooling system in 11C target and
then evaluated [11C]CO2 production at different beam currents, thickness of the target foil, oxygen content
of nitrogen gas and target gas loading pressure. Also, we evaluate the production of several 11C
radiopharmaceuticals such as [11C]PIB, [11C]DASB, and [11C]Clozapine.
Results: [11C]CO2 was produced about 74 GBq for 30min irradiation at 60 ㎂ of beam current as following conditions: thickness of the target foil: 19 nm HAVAR, oxygen content of nitrogen: under 50 ppb, target gas loading pressure: 24 bar. Additionally, the cooling system was stable to produce [11C]CO2 at high beam current. The radiochemical yields of [11C]PIB, [11C]DASB, and [11C]Clozapine showed about 26-38% with over 127 GBq/umol of specific activity.
Conclusion:The carbon-11 target system in the KOTRON-13 cyclotron was successfully developed and showed stable production of [11C]CO2. These results showed that our 11C target system will be compatible with other
commercial system for the routine 11C radiopharmaceuticals production in the KOTRON-13 cyclotron.
|
|
|
KEYWORD
|
|
|
KOTRON-13 , 11C target , cyclotron , [ 11C]CO2
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|